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个人学习工作简介
沈益忠, 博士, 副研究员/硕士生导师; 中国毒理学会分析毒理专业委员会青年委员, 《分析测试学报》青年编委。近年来, 主要从事环境分析化学与污染控制、食品质量安全分析与毒理评估、纳米生物分析等方面基础和应用研究。先后以第一/通讯作者在Chem. Soc. Rev., Environ. Sci. Technol., Anal. Chem., Nano Today, Appl. Catal. B Environ., Coord. Chem. Rev., Biomaterials, J. Hazard. Mater., Biosens. Bioelectron., Chem. Commun., Chem. Eng. J., ACS Appl. Mater. Interfaces, J. Agric. Food Chem., Food Chem., Food Chem. Toxicol.等期刊发表学术论文60余篇, 其中ESI 1%高被引论文2篇, Nature index论文10篇, Inside cover论文2篇, 单篇他引最高373次, 引用1456余次, 个人论文H指数19 (截止2023年1月份WOS数据)。主持承担国家自然科学基金（面上和青年项目各1项）、安徽省自然科学基金、中国博士后面上基金及横向委托等各类项目10余项。获2022年度中国分析测试协会科学技术奖一等奖1项（排名第2），2021年度安徽省科技进步二等奖1项（排名第7）。
主要研究领域与方向
1、 食品质量安全分析与毒理风险评估;
2、 环境分析化学与污染控制；
3、 纳米生物分析；
欢迎对食品/环境污染物分析检测与控制、毒理与风险评估、纳米生物分析研究感兴趣的同学报考！！！
开设课程
研究生 《现代仪器分析》
本科生 《生化仪器分析》
近三年代表性专著、论文、专利
论文(*通讯作者)：
1. Yizhong Shen*, Yunlong Wei, Xiang Gao, Chao Nie, Jianlong Wang*, and Yongning Wu ⃰. Engineering an enzymatic cascade catalytic smartphone-based sensor for onsite visual ratiometric fluorescence-colorimetric dual-mode detection of methyl mercaptan. Environ. Sci. Technol., 2023, 57, 1680−1691.
2. Chengyuan Yang, Jing Wang, Rong Wang, Wenxin Zhu, Liang Zhang, Ting Du, Jing Sun, Ming-Qiang Zhu, Yizhong Shen ⃰, and Jianlong Wang ⃰. Efficient hollow cubic Co9S8@defective ZnS/g-C3N4 for multi-pollutants removal via cascade Z-scheme heterojunction.Appl. Catal. B Environ., 2023, 322, 122084.
3. Yizhong Shen*, Xiang Gao, Hai-Jie Lu*, Chao Nie, and Jianlong Wang*. Electrochemiluminescence-based innovative sensors for monitoring the residual levels of heavy metal ions in environment-related matrices.Coord. Chem. Rev., 2023, 476, 214927.
4. Yuechun Li, Peng Wang, Lunjie Huang, Conghui Jia, Xiang Gao, Sijie Liu, Shaochi Wang, Peng Zhao, Jing Sun, Daohong Zhang, Mingqiang Zhu, Yizhong Shen*, and Jianlong Wang*. Schiff-base chemistry-coupled catechol oxidase-like nanozyme reaction as a universal sensing mode for ultrasensitive biosensing. Anal. Chem., 2023, DOI: 10.1021/acs.analchem.2c04897.
5. Zhiwei Lu, Maoting Chen, Tao Liu, Chun Wu, Mengmeng Sun, Gehong Su, Xianxiang Wang, Yanying Wang, Huadong Yin, Xinguang Zhou, Jianshan Ye, Yizhong Shen*, and Hanbing Rao*. Machine learning system to monitor Hg2+ and sulfide using a polychromatic fluorescence-colorimetric paper sensor.ACS Appl. Mater. Interfaces, 2023, DOI: 10.1021/acsami.2c16565.
6. Xiaoyi Lv, Fei Tan, Tian Miao, Bo Cui, Jianguo Zhang, Yishan Fang*, and Yizhong Shen*. In situ generated PtNPs to enhance electrochemiluminescence of multifunctional nanoreactor COP T4VTP6 for AFB1 detection. Food Chem., 2023, 399, 134002.
7. Jing Jing Zhang, Chao Nie, Wen Long Fu, Feng Li Cheng, Pu Chen, Zhong Feng Gao*, Yongning Wu, Yizhong Shen*. Photoresponsive DNA-modified magnetic bead-assisted rolling circle amplification-driven visual photothermal sensing of Escherichia coli. Anal. Chem., 2022, 94, 16796–16802.
8. Yizhong Shen*, Xiang Gao, Yiyin Zhang, Huanhuan Chen, Yingwang Ye*, and Yongning Wu*. Polydopamine-based nanozyme with dual-recognition strategy-driven fluorescence-colorimetric dual-mode platform for Listeria monocytogenes detection. J. Hazard. Mater, 2022, 439, 129582.
9. Ting Pan, Huanhuan Chen, Xiang Gao, Zeyu Wu, Yingwang Ye*, and Yizhong Shen*. Engineering efficient artificial nanozyme based on chitosan grafted Fe-doped-carbon dots for bacteria biofilm eradication. J. Hazard. Mater., 2022, 435, 128996.
10. Zhong Feng Gao*, Lin Lin Zheng, Lu Ming Dong, Jin Ze Li, Yizhong Shen*, Pu Chen*, and Fan Xia. Label-free resonance Rayleigh scattering amplification for lipopolysaccharide detection and logical circuit by CRISPR/Cas12a-driven guanine nanowire assisted non-cross-linking hybridization chain reaction. Anal. Chem., 2022, 94, 6371–6379.
11. Yizhong Shen*, Chao Nie, Yunlong Wei, Zhen-Lin Xu*, and Ping Xiang*. FRET-based innovative assays for precise detection of the residual heavy metals in food and agriculture-related matrices.Coord. Chem. Rev., 2022, 469, 214676.
12. Yizhong Shen*, Chao Nie, Chunlei Zhu, Zhi Zheng, and Yongning Wu*. Aggregation-induced emission fluorophore-incorporated curcumin-based ratiometric nanoprobe for hypochlorite detection in food matrices.J. Agric. Food Chem., 2022, 70, 9577–9583.
13. Yizhong Shen*, Yunlong Wei, Chunlei Zhu, Jinxuan Cao*, and De-Man Han*. Ratiometric fluorescent signals-driven smartphone-based portable sensors for onsite visual detection of food contaminants. Coord. Chem. Rev., 2022, 458, 214442.
14. Yizhong Shen, Tingting Wu, Huanhuan Chen, Yingwang Ye*, and Jing-Juan Xu*. Ratiometric fluorescence detection of pathogenic bacteria based on dual-recognition nanoprobes with controllable G-quadruplex release. Chem. Commun., 2022, 58, 447–450.
15. Yizhong Shen, Yiyin Zhang, Zhong Feng Gao, Yingwang Ye*, Qingping Wu, Hong-Yuan Chen, and Jing-Juan Xu*. Recent advances in nanotechnology for simultaneous detection of multiple pathogenic bacteria. Nano Today, 2021, 38, 101121.
16. Yizhong Shen, Tingting Wu, Yuqi Wang, Shao-Lin Zhang*, Xueli Zhao, Hong-Yuan Chen, and Jing-Juan Xu*. Nucleolin-targeted ratiometric fluorescent carbon dots with a remarkably large emission wavelength shift for precise imaging of cathepsin B in living cancer cells. Anal. Chem., 2021, 93, 4042–4050.
17. Keying Zhang, Guang Zhu, Yunlong Wei, Li Zhang, and Yizhong Shen*. Engineering of an upconversion luminescence sensing platform based on the competition effect for mercury-ion monitoring in green tea. J. Agric. Food Chem., 2021, 69, 8565–8570.
18. Yingwang Ye, Libing Zheng, Tingting Wu, Xiaowei Ding, Feng Chen, Yiying Yuan, Gao-Chao Fan, and Yizhong Shen*. Size-dependent modulation of polydopamine nanospheres on smart nanoprobes for detection of pathogenic bacteria at single-cell level and imaging-guided photothermal bactericidal activity. ACS Appl. Mater. Interfaces, 2020, 12, 35626–35637.
19. Yingwang Ye, Tingting Wu, Xiuting Jiang, Jinxuan Cao*, Xiao Ling, Qingsong Mei, Hua Chen, Deman Han, Jing-Juan Xu, and Yizhong Shen*. Portable smartphone-based QDs for the visual onsite monitoring of fluoroquinolone antibiotics in actual food and environmental samples. ACS Appl. Mater. Interfaces, 2020, 12, 14552–14562.
20. Yizhong Shen*, Tingting Wu, Yiyin Zhang, Na Ling, Libing Zheng, Shao-Lin Zhang*, Yidan Sun, Xiaohong Wang, and Yingwang Ye*. Engineering of dual-recognition ratiometric fluorescent nanosensor with remarkable large stokes shift for accurate tracking of pathogenic bacteria at single-cell level. Anal. Chem., 2020, 92, 13396–13404.
发明专利：
1. 沈益忠、陈欢欢、叶应旺、李辉、高翔. 铁单原子掺杂的荧光碳点纳米酶的制备方法. 申请号：202211634035.1.
2. 沈益忠、魏云龙、叶应旺、聂超. 一种利用Cu-g-C3N4纳米酶检测四环素残留的方法. 申请号：2021114745503; 公开号: CN114166772A.
3. 沈益忠、叶应旺、张译尹、高翔. 一种通过定量检测次黄嘌呤判别肉类新鲜度的方法. 申请号：2021115579322; 公开号: CN114113506A.
4. 沈益忠、朱春蕾、叶应旺、魏云龙、陈欢欢. 一种次氯酸根离子的检测方法. 申请号：2022100784954; 公开号: CN114441490A.
5. 叶德举、陈洪渊、徐静娟、沈益忠、孙一丹. 激活型纳米探针及其生物应用. 申请号：201711204248X; 授权公开号：CN107854689B.
指导学生获奖情况及社会活动等
1. 2021级聂超同学获2022年度硕士研究生国家奖学金
2. 2020级魏云龙同学获2022年度硕士研究生国家奖学金
3. 2018级吴婷婷同学荣获2019年度硕士研究生国家奖学金
4. 2018级吴婷婷同学荣获2019年度合肥工业大学优秀学术论文奖
5. 指导2021级本科同学获批2022年度国家级大学生创新训练项目(202210359074)
6. 指导2021级本科同学获批2022年度校级大学生创新训练项目(X202210359845)
7. 指导2017级本科同学获批2019年度国家级大学生创新训练项目(201910359065)
8. 指导2021级本科同学获安徽省获2022年度安徽省食品设计创新大赛二等奖
9. 指导本科生/研究生分别获2022年、2020年度大学生“互联网+”大赛校赛银奖和铜奖
10. 2022年度18款禁用软件app免费版青年教师教学比赛一等奖
11. 2020年度合肥工业大学本科招生宣传先进个人
